Best Sam-e supplements

Sam-e Supplements.

For most of us, old age is inevitable. No matter how old we tend to get, we can experience a gradual decline in our health. Our memory loses its sharpness, our bodies start to decline and we often tend to get pain in our joints. In fact, many of you may have it already or be at risk of developing inflammation in your joints or even osteoarthritis.

Don’t worry, while osteoarthritis and arthritis can’t be cured, the pain and inflammation can certainly be prevented or significantly reduced. One of the most unique forms of treatment for this is by using the SAM-e supplement. To know more about Sam-e supplements, take a look at our top 10 product list.

What is Sam-e?

Before going into detail about the supplement, let's break down S-Adenosyl-L-methionine (SAMe). For most of us, we will find SAMe in our bodies, as it’s a molecule. In addition to this, you can also make this ingredient artificially in the laboratory. Typically Sam-e plays an essential role in the formation, activation, and break down of hormones, proteins and phospholipids.

This ingredient was discovered in the 1950s and was first noted it came from methionine which is an amino acid present in food.

There have been some links to abnormal ranges of SAMe found in depression and also contributing to liver disease. Sam-e has also seemed to be helpful for people with arthritis too.

How does it work?

The most common way for Sam-e to work, is if you take an oral supplement and swallowing it, that's if you don't have enough levels in their body. If you do have enough levels then the live in your body will make Sam-E from methionine a protein that is found in many foods.

It sounds simple, but it's not. For Sam-E to be made there needs to be other helpers from other areas of your body too like folate, Vitamin B12, and other nutrients. Once made, your body utilizes the existing Sam-e to make specific chemicals that contribute to pain, depression, cirrhosis of the liver, and much more.

Sam-e Sumpliments How It Is Work.

Types of supplements

If you’re looking to buy Sam-e, it tends to be available from most pharmacies in tablets, capsules, and on odd occasions in powder form. You can get Sam-e too via an intravenous drip, but that’s the least common option. Depending on your condition and why you require SAM-e will influence the dose you take. The typical doses for Sam-e are 200mg, 800mg, and 1600mg. Before taking it, we suggest speaking to a doctor or pharmacist to know which is the right dose for you.

Best food sources

If you’re wanting to raise your levels of Sam-e in your body, without having to take supplements, you can always indulge in more food. The food you will want to will eat more of will need to contain the amino acid methionine which converts to Sam-e in your body. Typical foods that contain this protein are eggs, fish, brazil nuts, beef, turkey, tofu, cheese, and whole grains.

Sam-e benefits and conditions that can be treated

Sam-e has a fair bit of research behind it and its supplement version is taken for many purposes. The type of conditions that it can treat are:

  • Osteoarthritis - Sam-e if taken orally, can help contribute to the reduction of osteoarthritis symptoms from cropping up. However, the treatment will only be effective if you take aspirin and other medications designed to treat arthritis. Usually, if you have arthritis it will take at least a month, for the treatment to begin working.
  • Depression - If you take Sam-e orally through the form of an injection or shot then it’s often seemed to relieve the high symptoms of depression. Likewise depending on the dosage and how effective it is, it can replace antidepressants or work alongside them.

As mentioned above, these are two conditions that are treated with Sam-e. In addition to them, there are some which are classed as possibly effective, as the full research isn’t out just yet. The conditions which some believe Sam-e can treat are:

  • Cholestasis - This is where the body has a reduced amount of bile. If you take Sam-e orally via a supplement or an intravenous drip, it’s often shown to reduce the symptoms of Cholestasis.
  • Fibromyalgia - There’s a bit of debate, when it comes to Sam-E helping fibromyalgia. Some people claim it’s true, whereas some state there is not enough research out there. Those who claim it helps fibromyalgia have indicated that they experience symptoms of reduced pain, tender points, and numbness.
  • Sexual dysfunction - Alongside taking antidepressants, if you consume Sam-e orally, it’s often said it reduces sexual dysfunction.
  • Cirrhosis - Either via taking oral supplements or through an intravenous drip, people have mentioned if taken early, it can help improve liver function.

Sam-e Benefits And Conditions.

Side effects

Just like many medications and supplements, we can all be prone to some side effects. When it comes to taking Sam-e, most of the time they are mild. You can watch out for the following:

  • Sweating.
  • Irritability.
  • Anxiety.
  • Skin rashes.
  • Dizziness.
  • Insominia (mild).

Do note, if you suffer from bipolar disorder or severe depression, it’s essential that you consult with your doctor first before taking the medication. Because if you take it without consultation, it could increase your risk of mania and anxiety.

Following this, you should also seek your doctors advice if you have a compromised immune system. If you take this, you could put yourself at greater risk of infection due to the growth of a microorganism known as pneumocystis.

How long do I take Sam-e for?

There’s no set amount of time to take Sam-e, it really depends on why you’re taking it, the Sam-e dosage that’s been recommended to you, and the advice from your physician. Likewise, the amount or duration of time you take Sam-e can depend on the interactions it has with other medicines. Typically, Sam-e can interact with:

  • Antidepressants.
  • Narcotics.
  • Antipsychotics.
  • Levodopa.
  • Amphetamines.

Certain medications in these categories can affect the amount of serotonin to be produced, causing an over-production. Similarly, Sam-e can reduce the effectiveness of certain medications in these categories. Therefore you should consult with a doctor.

Side Effect Of Sam-e Sumpliment.


Sam-e is widely rated by many scientists for it helping depression, reducing pain in their joints, treating significant conditions such as arthritis, sexual dysfunction, cirrhosis, and much more. However, there is still a lot of skepticism within other areas of the scientific community as there needs to be more research done on the effects on health.

If you’re looking to purchase Sam-e we recommend speaking to your physician first for advice, then browsing lots of reviews and go to credible sources (if buying online). Make sure you mention any medications you’re currently taking to your physician before taking SAM-e.

To know more about Sam-e supplements, take a look at our top 10 product list.

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